Optimized Folate (L-Methylfolate) | 100 Veg Capsules | Life Extension

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  • Product Description
  • Supplement Facts
  • Usage Guide

Benefit your heart and mind

Folate, a member of the B-complex family, is involved in neurotransmitter synthesis and many other critical enzymatic reactions throughout the body. Optimal levels of this essential vitamin are necessary for healthy cell division and protein synthesis. In addition, folate helps maintain homocysteine levels within the normal range, thereby promoting cardiovascular health and nervous system function.

However, those who take ordinary folate supplements, may not be experiencing the full spectrum of benefits since not everyone is able to convert folate to its biologically active form, 5-methyltetrahydrofolate, or 5-MTHF. Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent this conversion, leaving many vulnerable to low blood folate levels and higher than desired homocysteine.

A more useful approach is the direct supplementation with the metabolically active form of folate called 5-MTHF, which is up to seven times more bioavailable than ordinary folic acid. This is also the answer for individuals with stubbornly elevated homocysteine levels who have a greater risk of cognitive decline.

Each vegetarian tablet of Optimized Folate contains 1.000 mcg of 5-MTHF, providing maximum support for both cardiovascular and cognitive health. Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12), vitamin B6, and riboflavin.

Supplement Facts

Serving Size 1 vegetarian tablet

Amount Per Serving

Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt]

1000 mcg

Other ingredients: microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.


Dosage and Use
  • Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.


  • Keep out of reach of children.
  • Do not exceed recommended daily dose.
  • Do not purchase if outer seal is broken or damaged.
  • If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult your medical practitioner first.
  • A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
  • Store tightly closed in a cool, dry place.

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